Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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Home About Us Advertise Amazon. Clinical manifestations of XGC are usually those of acute or chronic cholecystitis, but some patients present anorexia, nausea, vomiting, right upper quadrant pain and mass, suggesting gallbladder cancer. It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall Epidemiology of xanthogranulomatous cholecystitis.

Occasionally, XGC may closely mimic a gallbladder cancer or lead to complications such as perforation, abscess and fistula. More recently, these terms, together with other labels, such as ceroid granuloma, ceroid-like histiocytic granuloma of the gallbladder 2 and biliary granulomatous cholecystitis 3have been abandoned in favor of XGC, a descriptive term first used by McCoy et al 4. Dissection between the gallbladder serosa and hepatic parenchyma was difficult.

Xanthogranulomatous cholecystitis is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma. This is usually seen in association with dense fibrous tissue.

Pathology of Xanthogranulomatous Cholecystitis – Dr Sampurna Roy MD

XGC may be a high risk of postoperative wound infection and other septic complications because of frequent adhesion and abscess formation. No metaplasia, dysplasia or significant nuclear atypia is apparent. However, as XGC has the potential for fistula formation, Robert et al 6.

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A year-old male was admitted to Chonnam National University Hospital with a day history histopathooogy right upper quadrant pain with fever. Also, there appears to be a positive association between the two lesions.

The patient was discharged on postoperative day 10 without xanthogranulomagous. New author database being installed, click here for details. XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; radiologically, it is difficult to distinguish from gallbladder cancer.

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The sections show a thickened gallbladder wall with cholesterol clefts, multinucleated giant cells, fibrosis and small lymphoid aggregates. Yellow brown, poor to well demarcated foci of wall thickening with variable ulceration, simulates neoplasm.

There were also multiple black pigmented gallstones ranging from 0. The precursor lesions of invasive gallbladder carcinoma. J Am Coll Surg. Xanthogranulomatous cholecystitisabbreviated XGC[1] is an uncommon pathology of the gallbladder. Infectious etiology of xanthogranulomatous cholecystitis: Click here for information on linking to our website or using our content or images. This page was last modified on 30 Mayat Grossly the lesions are usually soft, yellow to brown, and measure up to 2.

Retrospective analysis of 12 cases. Lipid is ingested by macrophages, which have the appearance of xanthoma cells and giant cells of foreign- body and Touton type. Gallbladder Cholecystitis Xanthogranulomatous cholecystitis Author: On intraoperative cholangiogram through the cystic duct after cholecystectomy, there was no evidence of remaining stone or bile xanthogranulkmatous dilatation.


Benign tumors and pseudotumors of the gallbladder: The pathogenesis of XGC is unclear, although the role of lipid and bile is thought to be important. Dr Sampurna Roy MD. Hepatobiliary Pancreat Dis Int. Gastroenterol Res Pract Hyperplasia, atypical hyperplasia and carcinoma in situ.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

Retrieved from ” https: Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions. Computed tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement. J Indian Med Assoc ; Ann R Coll Surg Engl.

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. The true incidence of Xanthogranulomstous is difficult to establish because this disease is apparently a rare condition, although retrospective estimates of the incidence in cholecystectomy specimens range from 0. A retrospective Cohort study.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

On operation, the gallbladder wall was thickened and the serosa were surrounded by dense fibrous adhesions which were often extensive and attached to the adjacent hepatic parenchyma. LM cholesterol clefts, granulomas LM DDx chronic cholecystitisgallbladder cholesterolosis Gross thickened gallbladder wall, gallstones Site gallbladder Prevalence uncommon Radiology hypo-attenuated nodules in gallbladder wall Prognosis benign Xajthogranulomatous.

Xanthogranulomatous cholecystitis may form a tumour-like mass in inflamed gallbladders. A case report and review of literature.