Limbal dermoids rank among the most common tumors of the corneal limbus. They are ocular choristomas and can occur in a variety of sizes. Images in Clinical Medicine from The New England Journal of Medicine — Limbal Dermoid. Images in Clinical Medicine from The New England Journal of Medicine — The Hairy Eyeball — Limbal Dermoid.

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Hair may be seen in these fatty tumors as well. Tissue sources include a pericardial graft or amniotic membrane transplantation.

The main limitation of our trial is the small number of cases that forecloses adequate statistical reasoning from our results. Other techniques include corneal-limbal scleral donor graft transplantation and surgical resection followed by reconstructive sutureless multilayered amniotic membrane transplantation. Conjunctival epithelial cell differentiation on amniotic membrane.

MRI of the brain was completely normal. This was the patient’s first presentation for eye care. Ophthalmic Surg Laser Imaging.

Goldenhar Syndrome (Oculo-Auriculo-Vertebral Spectrum):

This article has been cited by other articles in PMC. TREATMENT Large eyelid colobomas resulting in exposure keratopathy may require surgical repair Spectacle Superficial keratectomy may be required to excise large limbal dermoids causing occlusive or astigmatic amblyopia or exposure Cleft lip and palate will require surgical repair, if present Severe underdevelopment of the mandible may require reconstruction, perhaps with the aide of a bone graft i.

The geneticist noted very subtle hemifacial microsomia, with the right side of the patient’s face being slightly smaller than the left. Residual corneal haze arrows indicates the former border of the excised dermoid. A removal of the pseudopterygium with the intraoperative use of Mitomycin C 0. Newborn infant lives at home with his parents.


Management of pediatric corneal limbal dermoids

The persistence of transplanted amniotic membrane in corneal stroma. Winces to light, both eyes OU. Eye Ear Nose Throat Mon. Published online Mar Group two consisted of three eyes that had been additionally treated with Mitomycin C 0.

Cultivation of corneal epithelial cells on intact and denuded human amniotic membrane. Mitomycin C as an antitumor antibiotic was first isolated from Streptomyces caespitosus in Anatomically, epibulbar dermoids have been classified into three grades. Fibrin glue-assisted augmented amniotic membrane transplantation for the treatment of large noninfectious corneal perforations. Gorlin RJ, et al. Then the complete lamellar en bloc excision of the corneal and scleral parts of the dermoid was performed including the removal of the entire adjacent conjunctiva.

One of these patients also had a central opacification of the cornea. Eur J Med Genet. Surgery is universally indicated for grade II and III limbal dermoids, given that they generally cause refractive or occlusive amblyopia Table 1. Clinical evaluation and surgical intervention of limbal dermoid. Vascularization developed postoperatively in two cases with previously excised lesions.

Double vision motility restriction or strabismus Dry eye exposure due to coloboma or large dermoid. The appropriate time of intervention and the best surgical technique for removal of the pediatric limbal dermoids are subject to discussion. Llmbal et al 5 reviewed the records of 12 patients with solid ocular tumors between andreporting that six lesions could be easily shaved off the cornea and adjacent sclera to improve the appearance of the eye.

Mean visual acuity was 0. Simple and direct excision of such lesions will inevitably result in restrictive strabismus and diplopia. Opacification of part of the graft was seen in Systemic treatment may be indicated for cardiac, renal, or CNS malformations.


One of these eyes was initially treated with bare-sclera excision; the other three eyes had undergone transplantation of amniotic membrane. Table 2 Guarded recommendations for surgical removal of ocular dermoids. Journal Derjoid Eye Lond v. Genetics and inheritance Rermoid pattern of inheritance is quite variable in epibulbar choristomas.

For grade III limbal dermoids, complete anterior segment reconstruction must be anticipated. They reported all but 16 eyes improved cosmetically. No hemivertebra nor butterfly vertebra were found on complete spine films. The group concluded multilayered amniotic membrane transplantation may be effective for the treatment of deep ulceration of the cornea and sclera. At first, the border of the limbal dermoid was marked using a trepan linbal a diamond blade. All patients had been treated consecutively in the past 9 years.

Amniotic membrane transplantation was carried out in four eyes. Limabl this, surgical removal of the limbal dermoid on the left side can be postponed indefinately.

Therapeutic lamellar keratoplasty for limbal dermoids. Histopathology, incidence, and pathogenesis Epibulbar dermoids may present as a single lesion or as multiple lesions.


Outcome of lamellar keratoplasty for limbal dermoids in children. Multilayer amniotic membrane transplantation in the treatment of corneal perforations. Deermoid Purpose We retrospectively studied the efficacy and safety of different surgical approaches to treating pediatric limbal dermoids with regard to intra and postoperative complications.

Long-term results of allogenic penetrating limbo-keratoplasty in total limbal stem cell deficiency. No eye treated with Mitomycin C developed a postoperative pseudopterygium Figure 4.