1 Aug Goodpasture syndrome is an autoimmune disorder. It occurs when the immune system mistakenly attacks and destroys healthy body tissue. This page includes the following topics and synonyms: Goodpastures Syndrome. Portuguese, SINDROME DE GOODPASTURE, Síndrome de Goodpasture. El síndrome de Goodpasture (SGP) es una rara entidad de base inmunológica, caracterizada por la asociación de una glome- rulonefritis rápidamente.

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Systemic vasculitis M30—M31 Expert curators review the literature and organize it to facilitate your work. Goodpasture’s syndrome in identical twins.

Goodpasture´s syndrome with neurologic involvement and negative ANCA

The following tests may also be done: Renal Glomerular Disorders Chapter. Laboratory analysis showed leukocytosis with a left shift, severe lactic acidosis, and negative anti-membrane antibodies, anti-nuclear antibodies, anti-neutrophil cytoplasmic antibodies, immunocomplexes, anti-DNA, anti-SS-A, anti-SS-B, anti-RNP, and anti-Scl, with normal complement and immunoglobulin levels. The urine analysis 24 hrs revealed a proteinuria of mg. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression.

Related Topics in Renal Glomerular Disorders. Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: They usually progress to end-stage renal failure that requires long-term dialysis. Goodpasture syndrome is an autoimmune disorder. After treatment with immunosuppressants and plasmapheresis, the patient showed reduced anti-GBM antibody titers and improved neurologic and respiratory symptoms, but renal failure persisted, requiring hemodialysis.

Perinuclear antineutrophilic cytoplasmic antibodies p-ANCAwhich can appear in Goodpasture syndrome, are also observed in Churg-Strauss vasculitis and occasionally in Wegener granulomatosis. Patients should address specific medical concerns with their physicians.

Goodpasture syndrome – Wikipedia

She did not recover renal function and we decided to start haemodialysis therapy using a tunnelled central venous catheter. Central nervous system involvement is highly unusual in the absence of anti-neutrophil cytoplasmic antibodies. Anti-glomerular basement membrane disease and Goodpasture disease. Osmosis Question of the Week. Exposure to organic solvents or hydrocarbons. Eduardo Salido for his advice on renal pathology and review of the manuscript. T cells enhance B-cell function and antibody production and may play a direct pathogenic role in kidney and lung injury.


Kidney Diseases Read more. Advances in human antiglomerular basement membrane disease. Brenner and Rector’s The Kidney. Aggressive therapy with plasmapheresis, corticosteroids, and immunosuppressive agents has dramatically improved prognosis.

The authors would like to thank Dr. Corticosteroid medicines such as prednisone and other drugs, which suppress or quiet the immune system. Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti—glomerular basement membrane anti-GBM antibodies. It is treated by controlling AHT, preferably using nicardipine or labetalol precaution is recommended when using nitroprusside due to the possibility of triggering paradoxical cerebral vasodilation that would worsen the cerebral oedemaand seizures are prevented with phenytoin or benzodiazepines.

Like other autoimmune conditions, anti-GBM disease is thought to result from an environmental insult in a person with genetic susceptibility. Goodpasture-syndromaGoodpasture syndroma. Characteristics and outcomes of patients with Goodpasture’s syndrome.

Goodpasture syndrome

The immune system’s faulty response causes sinrome in the air sacs of the lungs and inflammation in the kidney’s filtering units. However, anti-GBM disease is only one cause of pulmonary-renal syndromes, including Goodpasture syndrome. Related links to external sites from Bing. At this point, serial measurements of anti-BM Ab levels were negative, and in spite of the severity of the damage, the patient presented with no neurological deficit upon discharge.

The test can show crescent-shaped changes in the glomeruli and lines of antibodies attached to the GBM. Immunofluorescence staining for immunoglobulin IgG reveals diffuse, high-intensity, linear staining of the glomerular basement membrane in a patient with anti—glomerular basement membrane GBM disease.


Diseases of collagenlaminin and other scleroproteins. Renal transplantation in patients ve Alport syndrome. Chronic kidney disease End-stage kidney disease Lung failure Rapidly progressive glomerulonephritis Severe pulmonary hemorrhage lung bleeding. Prognosis In the past, Goodpasture syndrome was usually fatal.

Sinxrome patient continued to experience severe AHT that required treatment with 6 different drugs captopril, amlodipine, doxazosin, atenolol, nitroglycerin, and urapidil. Update on antiglomerular basement membrane disease. In our case, the patient sought treatment 4 months after developing the disease, when her anti-MBG antibodies were negative and she was not taking any immunosuppressant therapy.

A year-old man who previously smoked cigarettes heavily, developed massive hemoptysis.

Urinalysis is testing of a urine sample. CC ].

The health care provider may hear abnormal heart and lung sounds when listening to the chest with a stethoscope.

Making Sense of Nonspecific Symptomsa Critical Images slideshow, to help identify several diseases that can cause a variety of nonspecific symptoms.

With a third seizure and godpasture worsening of general health, the patient was admitted to the intensive care unit. A health care provider may order the following tests to diagnose Goodpasture syndrome: Graves’ disease Myasthenia gravis Pernicious anemia. It is thought to attack the snidrome subunit of type IV collagenwhich has therefore been referred to as Goodpasture’s antigen.

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